203 Inherited Diseases in Detail

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Learn about inherited diseases

Our genes play an essential part in what makes us human. Our inherited characteristics or ability is what connects us with our ancestors. Unfortunately, is that we also tend to inherit certain changes in our DNA that are not beneficial for our survival. These types of genetic mutations develop in various ways. A classical outlook is the Mendelian Inheritance which describes traits as dictated by dominant and recessive alleles of a gene. However, we later found out that the determination of traits is governed by much more complicated mechanisms, and this mode of inheritance is called Non-Mendelian Inheritance.

Non-mendelian inheritance does not follow the Mendelian laws, which means it does not depend on two alleles that dictate the dominant or recessive allele. Non-Mendelian inheritance depends on multiple alleles that do not show true dominance or recessiveness [1]. Non-mendelian also factors in the environment we live in.  Understanding the different modes of inheritance can help us comprehend the distinct mechanisms behind inherited diseases as well as learn the available treatments for the disease. These mechanisms, called cell signaling, describe the how and why events lead to genetic diseases. Recent developments in genetic engineering and medicine, such as computational analysis and gene therapy, have shown potential in diagnosing and treating inherited diseases. These advancements bring us one step closer to curing genetic diseases.

Required knowledge

This course is the next step in the world of inherited diseases. Preferably you have successfully finished our 101, 103, and 105 modules before entering this 203 course. 

How will you learn

Each course consists of several lessons (chapters), with each of several topics. The course includes film, animation, exercises, and quizzes to help to embed learning and to deepen understanding of the key concepts.
At the end of the course, you will be presented with a final quiz. Achieving an 80% score will be rewarded with the PHIX Genomics Academy 203 Advanced Inherited Diseases Certificate.

Learning Objectives

In this course, you will learn about the intricacies of inherited disease (ID) and its molecular mechanisms. It includes a subject on inherited metabolic diseases (IMD) and those common in the Philippines. You will also be able to familiarize yourself with various computational approaches used as diagnostic tool for ID and treatments such as gene therapy. By the end of the course, you will have a better comprehension of molecular, diagnostic, and treatment of ID.

Key concepts covered

  • the intricacies of inherited disease (ID) and its molecular mechanisms
  • cell signaling
  • inherited metabolic diseases (IMD) and those common in the Philippines
  • various computational approaches used as a diagnostic tool for ID
  • treatments such as gene therapy


This course is developed and owned by PHIX Genomics Inc., inspired by its mission to bring genomic innovations to the Philippines and SE Asia. The PHIX Genomics Academy is happy to invite you to take this e-learning.

Your investment

This course will approximately take 60 minutes. It is a mandatory module to certify for the curricula PHIX Certified Internist Genomics Practitioner and PHIX Certified Pediatric Genomics Practitioner of the PHIX Genomics Academy.

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