203: Inherited Diseases in Detail

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Learn about Inherited Diseases

Our genes play an essential part in what makes us human. Our inherited characteristics or abilities is what connects us with our ancestors. Unfortunately, is that we also tend to inherit certain changes in our DNA that are not beneficial for our survival. These types of genetic mutations develop in various ways. A classical outlook is the Mendelian Inheritance which describes traits as dictated by dominant and recessive alleles of a gene. However, we later found out that the determination of traits is governed by much more complicated mechanisms, as shown in another mode of inheritance called Non-Mendelian Inheritance.

Non-Mendelian inheritance does not follow the Mendelian laws, which means it does not depend solely on two alleles that dictate the dominant or recessive gene. Non-Mendelian inheritance depends on multiple alleles that do not show true dominance or recessiveness1. The environment we live in is also a contributing factor to non-Mendelian traits.  Understanding the different modes of inheritance can help us comprehend the distinct mechanisms behind inherited diseases as well as learn the available treatments for the disease. These mechanisms, called cell signaling, describe the “how” and “why” events that lead to genetic diseases. Recent developments in genetic engineering and medicine, such as computational analysis and gene therapy, have shown potential in diagnosing and treating inherited diseases. These advancements bring us one step closer to curing genetic diseases.

Key Concepts Covered

  • The intricacies of inherited disease (ID) and its molecular mechanisms
  • Cell signaling
  • Inherited metabolic diseases (IMD) and those common in the Philippines
  • Various computational approaches used as a diagnostic tool for ID
  • Treatments such as gene therapy

 Tip! Want to know first what’s in the course? Click on ‘Expand All’ and scroll down.

Your Investment

This course will take approximately 8 hours. Course materials are accessible for a month after date of enrollment.

Required Knowledge

This course is the next step in the world of inherited diseases. Preferably you have successfully finished the following courses:

  • 101: Genomics in Modern-Day Healthcare
  • 102: Basics of Genomics and Oncology
  • 103: Genes, Inherited Diseases, and Pregnancy

How Will You Learn?

The course includes film, animation, exercises, and quizzes to embed learning and deepen your understanding of the key concepts. There are knowledge checks where you take the role of a practicing doctor, with expert comments afterward, so that you can learn from the experts in the field.

At the end of the course, you will be presented with a final quiz. Achieving an 80% score will be rewarded with the PHIX Genomics Academy 203 Genomics Certificate. In the bonus lesson, you will find extra material, such as links to additional information and the complete glossary.


Finishing this course will grant you a certificate of participation. It is mandatory training to certify for all the curricula of the PHIX Genomics Academy.


This course is developed and owned by PHIX Genomics Inc., inspired by its mission to bring genomic innovations to the Philippines and SE Asia.
The PHIX Genomics Academy is happy to invite you to take this e-learning.

This course is based on material from external sources. We gratefully thank all institutions and organizations for their effortless input to further the field of genomics and help improve people’s lives all over the world. We have taken considerable care to make fair use for educational purposes only. Please contact us if you are the rightful owner of the used material and feel any infringement is at stake.

Ready to start working on your career?

– Click on ‘Lesson 1’ below to start the course.
– You can pause any time you want, go forward or back at your own choice.
– When you feel happy with the material and ideas covered in a step, press ‘Show next chapter’ to complete the topic and record your progress.  You can then click ‘Next Topic’ to continue or press ‘Previous Lesson’ to return to the preceding lessons.
– At each lesson introduction, the ‘Back to Course’  button is available if you want to be redirected to this page. When on a subtopic page, ‘Back to Lesson’  brings you back to the lesson introduction.
– You can always come back to a step even after the end of the course.
– There will be a final quiz at the end of the course, and more details will be provided once this step is reached.


  1. Lakna, B. (2017, August 5). Difference between mendelian and non mendelian inheritance | definition, features, fundamental laws of inheritance. Pediaa.Com. https://pediaa.com/difference-between-mendelian-and-non-mendelian-inheritance/.

Course Content

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